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Curr Opin Immunol. 2018 Apr;51:76-82. doi: 10.1016/j.coi.2018.03.009. Epub 2018 Mar 14.

Plasticity of myeloid-derived suppressor cells in cancer.

Author information

1
The Wistar Institute, Philadelphia, PA 19104, United States.
2
University of Pennsylvania, Philadelphia, PA, United States.
3
The Wistar Institute, Philadelphia, PA 19104, United States; University of Pennsylvania, Philadelphia, PA, United States. Electronic address: dgabrilovich@wistar.org.

Abstract

In recent years, myeloid-derived suppressor cells (MDSC) have emerged as one of the major inhibitors of immune effector cell function in cancer. MDSC represent a heterogeneous population of largely immature myeloid cells that are characterized by a pathological state of activation and display potent immune suppressive activity. Two major subsets of MDSC have been identified: monocytic (M-MDSC) and polymorphonuclear (PMN-MDSC). PMN-MSDC share phenotypic and morphologic features with neutrophils, whereas M-MDSC are similar to monocytes and are characterized by high plasticity. Differentiation of M-MDSC to macrophages and dendritic cells is shaped by tumor microenvironment. In recent years, the mechanisms of this process start to emerge.

PMID:
29547768
PMCID:
PMC5943174
DOI:
10.1016/j.coi.2018.03.009
[Indexed for MEDLINE]
Free PMC Article

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