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Phys Rev Lett. 2018 Mar 2;120(9):098001. doi: 10.1103/PhysRevLett.120.098001.

Maximal Fluctuations of Confined Actomyosin Gels: Dynamics of the Cell Nucleus.

Author information

1
Mechanobiology Institute, National University of Singapore, 5A Engineering Drive 1, 117411 Singapore, Singapore.
2
Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, TIFR, Bangalore 560065, India.
3
Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France.

Abstract

We investigate the effect of stress fluctuations on the stochastic dynamics of an inclusion embedded in a viscous gel. We show that, in nonequilibrium systems, stress fluctuations give rise to an effective attraction towards the boundaries of the confining domain, which is reminiscent of an active Casimir effect. We apply this generic result to the dynamics of deformations of the cell nucleus, and we demonstrate the appearance of a fluctuation maximum at a critical level of activity, in agreement with recent experiments [E. Makhija, D. S. Jokhun, and G. V. Shivashankar, Proc. Natl. Acad. Sci. U.S.A. 113, E32 (2016)PNASA60027-842410.1073/pnas.1513189113].

PMID:
29547335
DOI:
10.1103/PhysRevLett.120.098001
[Indexed for MEDLINE]

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