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Med Sci (Paris). 2018 Mar;34(3):247-252. doi: 10.1051/medsci/20183403013. Epub 2018 Mar 16.

[Sex-bias in allergic asthma: androgens and group 2 innate lymphoid cells].

[Article in French]

Author information

1
Centre de physiopathologie de Toulouse Purpan (CPTP), Université de Toulouse, Inserm, CNRS, UPS, 31300 Toulouse, France.

Abstract

Allergic asthma is a chronic pulmonary inflammatory disease initiated by exposure to normally harmless allergens and marked by bronchial hyperreactivity. It affects more than 300 million people worldwide. Asthma often starts in childhood. Epidemiological studies show that there are sexual disparities in the prevalence and severity of asthma. Before the age of 10, the disease is more common in boys. This tendency reverses at puberty suggesting a regulating role of the sex hormones. In this synthesis, we summarize current knowledge on the role of sex hormones in allergic inflammation, with a particular focus on the impact of androgens on the development and function of recently introduced group 2 innate lymphoid cell subsets (ILC2) as critical actors in the initiation of allergic responses.♢.

PMID:
29547111
DOI:
10.1051/medsci/20183403013
[Indexed for MEDLINE]

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