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CNS Neurol Disord Drug Targets. 2018;17(2):132-143. doi: 10.2174/1871527317666180315170146.

An Investigation of the Effects of Curcumin on the Changes in the Central Nervous System of Rats Exposed to Aroclor 1254 in the Prenatal Period.

Author information

1
Department of Pathology, Faculty of Veterinary Medicine, Kirikkale University, Kirikkale, Turkey.
2
Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
3
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.
4
Biochemistry Labaratory, Sivas Numune Hospital, Sivas, Turkey.
5
Department of Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
6
Laboratory of Experimental Animal Research, Faculty of Medicine, Ankara University, Ankara, Turkey.

Abstract

BACKGROUND & OBJECTIVE:

Aroclor 1254 is a widespread toxic compound of Polychlorinated Biphenyls (PCBs), which can create significant nervous problems. No remedies have been found to date. The aim of this study was to reveal the damage that occurs in the central nervous system of rat pups exposed to Aroclor 1254 in the prenatal period and to show the inhibiting effect of curcumin, which is a strong anti-oxidant and neuroprotective substance.

METHOD:

The study established 3 groups of adult female and male Wistar albino rats. The rats were mated within these groups and the offspring rats were evaluated within the group given Aroclor 1254 only (n=10) and the group was given both Aroclor 1254 and curcumin (n=10) and the control group (n=10). The groups were compared in respect of pathomorphological damage. The immunohistochemical evaluation was made of 8-hydroxdeoxyguanosine (8-OHdG), 4-hydroxynoneal (4HNE), myelin basic protein (MBP) expressions and TUNEL reaction. The biochemical evaluation was made of the changes in the TAS-TOS and Neuron Specific Enolase (NSE) levels. Damage was seen to have been reduced with curcumin in the 8OHdG and TUNEL reactions, especially in the forebrain and the midbrain, although the dosage applied did not significantly change TAS and TOS levels. Consequently, it was understood that Aroclor 1254 caused damage in the central nervous system of the pup in the prenatal period, and curcumin reduced these negative effects, particularly in the forebrain and the midbrain.

CONCLUSION:

It was concluded that curcumin could be a potential neuroprotective agent and would be more effective at higher doses.

KEYWORDS:

Aroclor 1254; biochemistry; curcumin; immunohistochemistry; pathomorphology; rat pups.

[Indexed for MEDLINE]

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