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Biomed Res Int. 2018 Feb 6;2018:3140983. doi: 10.1155/2018/3140983. eCollection 2018.

Liver Illness and Psoriatic Patients.

Author information

1
Department of Anaesthesiological, Surgical and Emergency Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
2
Department of Medicine, Division of Infectious Diseases, "San Giuseppe Moscati" Hospital, Avellino, Italy.
3
Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples Federico II, Naples, Italy.
4
Department of Pathophysiology and Transplantation, Dermatology Unit, IRCCS Ca' Granda, University of Milan, Milan, Italy.
5
Study Center of Young Dermatologists Italian Network (YDIN), Bergamo, Italy.

Abstract

Psoriasis is a chronic inflammatory disease of the skin affecting approximately 2% of the world's population. Systemic treatments, including methotrexate and cyclosporin, are associated with potential hepatotoxicity, due to either direct liver damage or immunosuppression or both immunomediated and a direct liver injury; therefore, treatment of patients with psoriasis poses a therapeutic challenge. The aim of this minireview is to help clinicians in the management of psoriatic patients who develop signs of liver dysfunction. To find relevant articles, a comprehensive search was performed on PubMed, EMBASE, and Cochrane with appropriate combinations of the following keywords being considered: viral hepatitis, nonalcoholic fatty liver disease, psoriasis, hepatotoxicity, drug toxicity, cholestasis, and autoimmune liver diseases.

PMID:
29546055
PMCID:
PMC5818942
DOI:
10.1155/2018/3140983
[Indexed for MEDLINE]
Free PMC Article

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