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Semin Perinatol. 2018 Apr;42(3):168-175. doi: 10.1053/j.semperi.2018.02.004. Epub 2018 Mar 12.

Neonatal herpes simplex virus infections.

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Department of Pediatrics, University of Nebraska Medical Center, 982167 Nebraska Medical Center, Omaha, NE 68198.
Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, 1600 Seventh Avenue South, CHB 303, Birmingham, AL 35233. Electronic address:


Neonatal herpes simplex virus (HSV) is an uncommon but devastating infection in the newborn, associated with significant morbidity and mortality. The use of PCR for identification of infected infants and acyclovir for treatment has significantly improved the prognosis for affected infants. The subsequent use of suppressive therapy with oral acyclovir following completion of parenteral treatment of acute disease has further enhanced the long-term prognosis for these infants. This review article will discuss the epidemiology, risk factors and routes of acquisition, clinical presentation, and evaluation of an infant suspected to have the infection, and treatment of proven neonatal HSV disease.


Acyclovir; HSV; Neonatal; PCR

[Indexed for MEDLINE]

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