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Vitam Horm. 2018;107:67-87. doi: 10.1016/bs.vh.2018.01.010. Epub 2018 Feb 19.

Regulation of Luteinizing Hormone Receptor mRNA Expression in the Ovary: The Role of miR-122.

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The University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address:
The University of Michigan Medical School, Ann Arbor, MI, United States.


The expression of luteinizing hormone receptor (LHR) in the mammalian ovary is regulated in response to changes in the secretion of follicle-stimulating hormone and luteinizing hormone by the anterior pituitary, at least in part, through posttranscriptional mechanisms. The steady-state levels of LHR mRNA are maintained by controlling its rate of degradation by an RNA-binding protein designated as LHR mRNA-binding protein (LRBP). LRBP forms a complex with LHR mRNA and targets it for degradation in the p bodies. miR-122, an 18 nucleotide noncoding RNA, regulates the expression of LRBP. Thus, the levels of miR-122 determine the cellular levels of LHR mRNA expression. This phenomenon has been examined during the induction of LHR mRNA expression that occurs during follicle maturation in response to rising levels of FSH. In this situation, miR-122 and LRBP levels decrease as LHR mRNA expression undergoes downregulation in response to preovulatory LH surge. miR-122 expression as well as LRBP levels show robust increases. The mechanism of induction of LRBP by miR-122 has also been discussed.


G protein-coupled receptors; Hormone receptor regulation; LH receptor; Mevalonate kinase; Noncoding RNA; Ovary; Posttranscriptional regulation; RNA-binding protein; Reproductive function; microRNA

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