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PLoS Pathog. 2018 Mar 15;14(3):e1006839. doi: 10.1371/journal.ppat.1006839. eCollection 2018 Mar.

Viral manipulation of STAT3: Evade, exploit, and injure.

Author information

1
Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.
2
Université de Strasbourg, Strasbourg, France.
3
Pôle Hépato-digestif, Institut Hospitalo-universitaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Abstract

Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy.

PMID:
29543893
PMCID:
PMC5854428
DOI:
10.1371/journal.ppat.1006839
[Indexed for MEDLINE]
Free PMC Article

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