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Curr Opin Cardiol. 2018 May;33(3):282-289. doi: 10.1097/HCO.0000000000000507.

The long noncoding RNA landscape in cardiovascular disease: a brief update.

Author information

1
Department of Cardiovascular Medicine, Humanitas Research Hospital.
2
Humanitas University, Milan.
3
Department of Medicine and Surgery, Biotechnological and Translational Sciences, University of Parma, Parma.
4
Institute of Genetic and Biomedical Research, National Research Council of Italy, Milan, Italy.

Abstract

PURPOSE OF REVIEW:

In this review, we summarize new knowledge on long noncoding RNAs (lncRNAs) linked to cardiovascular disease, in particular to heart failure.

RECENT FINDINGS:

LncRNAs are dysregulated in specific developmental and pathological conditions and regulate critical responses to stress. LncRNAs are being recognized as molecules regulating myocardial remodeling during disease, participating for instance in the regulation of cardiomyocyte hypertrophy and function and fibroblast proliferation.

SUMMARY:

LncRNAs add a new layer of complexity to the regulation of the biological processes underlying normal cardiac development and myocardial remodeling during disease; they may represent targets for novel therapeutic strategies for cardiovascular diseases.

PMID:
29543669
DOI:
10.1097/HCO.0000000000000507
[Indexed for MEDLINE]

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