Mechanisms and disease relevance of neutrophil extracellular trap formation

Kristof Van Avondt; Dominik Hartl

doi:10.1111/eci.12919

Mechanisms and disease relevance of neutrophil extracellular trap formation

Eur J Clin Invest. 2018 Nov:48 Suppl 2:e12919. doi: 10.1111/eci.12919. Epub 2018 Apr 2.

Authors

Kristof Van Avondt¹, Dominik Hartl²

Affiliations

¹ Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
² Children's Hospital, University of Tübingen, Tübingen, Germany.

PMID: 29543328
DOI: 10.1111/eci.12919

Abstract

While the microscopic appearance of neutrophil extracellular traps (NETs) has fascinated basic researchers since its discovery, the (patho)physiological mechanisms triggering NET release, the disease relevance and clinical translatability of this unconventional cellular mechanism remained poorly understood. Here, we summarize and discuss current concepts of the mechanisms and disease relevance of NET formation.

Keywords: inflammation; neutrophil extracellular traps; neutrophils.

Publication types

Review

MeSH terms

Autoimmune Diseases / physiopathology
Bacterial Infections / physiopathology
Cell Death / physiology
Extracellular Traps / physiology*
Forecasting
Humans
Mycoses / physiopathology
Neutrophils / physiology*
Signal Transduction / physiology