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Head Neck. 2018 Jul;40(7):1598-1604. doi: 10.1002/hed.25140. Epub 2018 Mar 15.

Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma.

Author information

1
Department of Oral and Maxillofacial Surgery, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
2
Translational Laboratory Team, University of Birmingham, Birmingham, United Kingdom.
3
Department of Cancer and Genetics, University of Birmingham, Birmingham, United Kingdom.
4
Department of Head and Neck Surgery, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
5
Department of Clinical Oncology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
6
Institute of Head and Neck Studies and Education, Department of Head and Neck Surgery, University of Birmingham, Birmingham, United Kingdom.

Abstract

The use of circulating biochemical molecular markers in head and neck cancer holds the promise of improved diagnostics, treatment planning, and posttreatment surveillance. In this review, we provide an introduction for the head and neck surgeon of the basic science, current evidence, and future applications of circulating tumor DNA (ctDNA) as a biomarker and liquid biopsy to detect tumor genetic heterogeneity in patients with head and neck squamous cell carcinoma (HNSCC).

KEYWORDS:

biomarker; circulating tumor DNA (ctDNA); head and neck cancer; liquid biopsy

PMID:
29542214
DOI:
10.1002/hed.25140
[Indexed for MEDLINE]

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