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Stem Cell Rev. 2018 Jun;14(3):309-322. doi: 10.1007/s12015-018-9808-y.

Cell Cycle Regulation of Stem Cells by MicroRNAs.

Author information

1
Department of Epidemiology, Erasmus University Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
2
Department of Epidemiology, Erasmus University Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. m.ghanbari@erasmusmc.nl.
3
Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. m.ghanbari@erasmusmc.nl.

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the regulation of gene expression. They are involved in the fine-tuning of fundamental biological processes such as proliferation, differentiation, survival and apoptosis in many cell types. Emerging evidence suggests that miRNAs regulate critical pathways involved in stem cell function. Several miRNAs have been suggested to target transcripts that directly or indirectly coordinate the cell cycle progression of stem cells. Moreover, previous studies have shown that altered expression levels of miRNAs can contribute to pathological conditions, such as cancer, due to the loss of cell cycle regulation. However, the precise mechanism underlying miRNA-mediated regulation of cell cycle in stem cells is still incompletely understood. In this review, we discuss current knowledge of miRNAs regulatory role in cell cycle progression of stem cells. We describe how specific miRNAs may control cell cycle associated molecules and checkpoints in embryonic, somatic and cancer stem cells. We further outline how these miRNAs could be regulated to influence cell cycle progression in stem cells as a potential clinical application.

KEYWORDS:

Cancer stem cell; Cell cycle; ESC; MicroRNA; Somatic stem cell; Stem cells

PMID:
29541978
PMCID:
PMC5960494
DOI:
10.1007/s12015-018-9808-y
[Indexed for MEDLINE]
Free PMC Article

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