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Biomed Opt Express. 2018 Feb 1;9(3):921-932. doi: 10.1364/BOE.9.000921. eCollection 2018 Mar 1.

Optical properties of acute kidney injury measured by quantitative phase imaging.

Author information

1
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
2
These authors contributed equally to this work.
3
Rowland Institute, Harvard University, Boston, Massachusetts, USA.
4
Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
5
Quantitative Light Imaging Laboratory, Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
6
gpopescu@illinois.edu.
7
wgjung@unist.ac.kr.

Abstract

The diagnosis of acute kidney disease (AKI) has been examined mainly by histology, immunohistochemistry and western blot. Though these approaches are widely accepted in the field, it has an inherent limitation due to the lack of high-throughput and quantitative information. For a better understanding of prognosis in AKI, we present a new approach using quantitative phase imaging combined with a wide-field scanning platform. Through the phase-delay information from the tissue, we were able to predict a stage of AKI based on various optical properties such as light scattering coefficient and anisotropy. These optical parameters quantify the deterioration process of the AKI model of tissue. Our device would be a very useful tool when it is required to deliver fast feedback of tissue pathology or when diseases are related to mechanical properties such as fibrosis.

KEYWORDS:

(110.3080) Quantitative phase imaging; (120.5050) Phase measurement; (160.4760) Optical properties; (180.3170) Interference microscopy; (290.5820) Scattering measurements

Conflict of interest statement

The authors declare that there are no conflicts of interest related to this article.

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