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Bone Marrow Transplant. 2018 Sep;53(9):1139-1148. doi: 10.1038/s41409-018-0153-1. Epub 2018 Mar 14.

Is the use of unrelated donor transplantation leveling off in Europe? The 2016 European Society for Blood and Marrow Transplant activity survey report.

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EBMT Activity Survey Office, Hematology, Department of Medicine, University Hospital, Basel, Switzerland.
EBMT Activity Survey Office, Hematology, Department of Medicine, University Hospital, Basel, Switzerland.
Universitätsklinikum Frankfurt, Goethe-Universität, Frankfurt am Main, Germany.
Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
Università Vita-Salute San Raffaele, Milan, Italy.
Servicio de Hematologia y Hemoterapia, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Hematology Unit, G. Gaslini Children's Institute, Genova, Italy.
Department of Stem Cell Transplantation, University Hospital Eppendorf, Hamburg, Germany.
Department of Haematology, University Medical Centre, Utrecht, The Netherlands.
Department of Pediatrics, Leiden University Medical Centre Leiden, Leiden, The Netherlands.
St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Sheffield Teaching Hospitals NHS Foundation, Royal Hallamshire Hospital, Sheffield, UK.
Pediatric Hematology and Oncology, University Hospital, Collegium Medicum UMK, Bydgoszcz, Poland.
Department of Hematology, Hospital Saint Antoine, Paris, France.


Hematopoietic cell transplantation (HCT) is an established procedure for acquired and congenital disorders of the hematopoietic system. In 2016, there was a tendency for continued activity in this field with 43,636 HCT in 39,313 patients [16,507 allogeneic (42%), 22,806 autologous (58%)] reported by 679 centers in 49 countries in 2016. The main indications were myeloid malignancies 9547 (24%; 96% allogeneic), lymphoid malignancies 25,618 (65%; 20% allogeneic), solid tumors 1516 (4%; 2% allogeneic), and non-malignant disorders 2459 (6%; 85% allogeneic). There was a remarkable leveling off in the use of unrelated donor HCT being replaced by haploidentical HCT. Continued growth in allogeneic HCT for marrow failure, AML, and MPN was seen, whereas MDS appears stable. Allogeneic HCT for lymphoid malignancies vary in trend with increases for NHL and decreases for Hodgkin lymphoma and myeloma. Trends in CLL are not clear, with recent increases after a decrease in activity. In autologous HCT, the use in myeloma continues to expand but is stable in Hodgkin lymphoma. There is a notable increase in autologous HCT for autoimmune disease. These data reflect the most recent advances in the field, in which some trends and changes are likely to be related to development of non-transplant technologies.

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