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Int Arch Allergy Immunol. 2018;175(4):231-236. doi: 10.1159/000486959. Epub 2018 Mar 14.

Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis.

Abstract

BACKGROUND:

Resveratrol is a natural, nonflavonoid polyphenol, exerting anti-inflammatory activity. It has been reported that resveratrol, together with carboxymethyl-β-glucan, can reduce nasal symptoms in children with allergic rhinitis (AR). In this study, the effect of resveratrol on nasal symptoms in adults with AR was investigated.

METHODS:

We conducted a placebo-controlled, double-blinded study. One hundred and fifty-one adults (aged 18-60 years) with severe persistent AR were divided into a placebo-treated group (n = 50), a positive control budesonide-treated group (n = 50), and a resveratrol-treated group (n = 51). They were then treated with 2 sprays (100 µL/spray) in each nostril 3 times/day for 1 month. Nasal symptoms including obstruction, itching, sneezing, and rhinorrhea, and the levels of IgE, IL-4, TNF-α, and eosinophils in the blood were assessed at baseline and after treatment.

RESULTS:

Adults treated with resveratrol or budesonide achieved a significant reduction in nasal symptoms compared to the placebo-treated group. The resveratrol treatment significantly decreased the IgE, IL-4, TNF-α, and eosinophil levels in the blood. In addition, the resveratrol treatment was found to improve the quality of life of adults with AR.

CONCLUSION:

Our preliminary study showed that intranasal resveratrol is capable of significantly improving nasal symptoms in adults with AR.

KEYWORDS:

Adult; Allergic rhinitis; Eosinophils; Nasal symptoms; Resveratrol

PMID:
29539616
DOI:
10.1159/000486959
[Indexed for MEDLINE]

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