Send to

Choose Destination
Annu Rev Plant Biol. 2018 Apr 29;69:173-208. doi: 10.1146/annurev-arplant-042817-040606. Epub 2018 Mar 14.

Autophagy: The Master of Bulk and Selective Recycling.

Author information

Department of Biology, Washington University in St. Louis, St. Louis, Missouri 63130, USA; email:


Plants have evolved sophisticated mechanisms to recycle intracellular constituents, which are essential for developmental and metabolic transitions; for efficient nutrient reuse; and for the proper disposal of proteins, protein complexes, and even entire organelles that become obsolete or dysfunctional. One major route is autophagy, which employs specialized vesicles to encapsulate and deliver cytoplasmic material to the vacuole for breakdown. In the past decade, the mechanics of autophagy and the scores of components involved in autophagic vesicle assembly have been documented. Now emerging is the importance of dedicated receptors that help recruit appropriate cargo, which in many cases exploit ubiquitylation as a signal. Although operating at a low constitutive level in all plant cells, autophagy is upregulated during senescence and various environmental challenges and is essential for proper nutrient allocation. Its importance to plant metabolism and energy balance in particular places autophagy at the nexus of robust crop performance, especially under suboptimal conditions.


autophagic receptors; membrane trafficking; metabolism; proteolysis; ubiquitin; vacuole

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center