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Nat Prod Res. 2018 Mar 14:1-4. doi: 10.1080/14786419.2018.1448979. [Epub ahead of print]

The antifungal activity of essential oil from Melaleuca leucadendra (L.) L. grown in China and its synergistic effects with conventional antibiotics against Candida.

Author information

1
a Anhui Prevention and Treatment Center for Occupational Disease , Anhui No. 2 Province People's Hospital , Hefei , China.
2
b Jiangsu Nature Biological Engineering Technology Co., Ltd , Nanjing , China.
3
c School of Pharmacy , Anhui Medical University , Hefei , China.
4
d School of Basic Medical , Anhui Medical University , Hefei , China.

Abstract

To identify the natural antifungal agents, the antifungal activities of Melaleuca leucadendra (L.) L. essential oil (ML-EO) from Fujian Province of China were assayed. Treatment of ML-EO in combination with the front-line using antibiotics against Candida led to synergistic effects. Electron microscopy analysis on the oil treated C. albicans cells revealed the formation of mesosome-like structures, suggesting well the membrane damage caused by the essential oil. The Griess assay by monitoring NO production in LPS-stimulated RAW264.7 cells indicated the potent anti-inflammatory activity of ML-EO. In comparison with the marked essential oil of Melaleuca alternifolia EO, ML-EO had almost the same chemical components. In general, the antifungal activity of ML-EO and its synergistic interactions with conventional antibiotics were able to lead the development of new treatment strategies on Candida infection.

KEYWORDS:

Candida; Melaleuca leucadendron; antifungi; essential oil; synergistic interaction

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