Format

Send to

Choose Destination
Pathol Int. 2018 May;68(5):294-300. doi: 10.1111/pin.12657. Epub 2018 Mar 14.

Clinicopathological and prognostic significance of heme oxygenase-1 expression in small intestinal adenocarcinomas.

Author information

1
Department of Pathology, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Republic of Korea.
2
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
3
Department of Pathology, Yeungnam University College of Medicine, Daegu, Republic of Korea.
4
Department of Pathology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
5
Department of Pathology, Chonbuk National University Medical School, Jeonju, Republic of Korea.
6
Department of Pathology, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Republic of Korea.

Abstract

Heme oxygenase-1 (HO-1), a stress-response protein, is highly induced in various carcinomas. It is implicated in carcinogenesis and tumor progression. High HO-1 expression is associated with better prognosis of patients with colorectal and gastric cancers. Induction or inhibition of HO-1 can mediate chemo-sensitivity, therefore it might be a therapeutic target to develop anticancer agents. To define the clinicopathological and prognostic significance of HO-1 expression in small-intestinal adenocarcinomas (SIACs), immunohistochemical microarray analysis of HO-1 expression was performed for 191 surgically resected SIAC cases and results were compared with various clinicopathologic variables, including survival. HO-1 was highly expressed in 127 (66.5%) cases. Patients with high HO-1 expression were associated with younger age (P = 0.048), lower pT category (P = 0.017), and less pancreatic invasion (P = 0.047). Patients with high HO-1 expression tended to have longer overall survival (median, 38.5 months) than those with low HO-1 expression (24.5 months), although the difference in overall survival was not statistically significant (P = 0.677). In summary, high HO-1 expression is frequently observed in SIACs. It is related to favorable clinicopathologic parameters, including younger age, lower T category, and less pancreatic invasion. Therefore, HO-1 may serve as a prognostic marker and a new target to modulate chemotherapeutic effects in patients with SIACs.

KEYWORDS:

heme oxygenase-1; immunohistochemistry; small intestine; survival

PMID:
29537718
DOI:
10.1111/pin.12657
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center