Send to

Choose Destination
Org Lett. 2018 Apr 6;20(7):1824-1827. doi: 10.1021/acs.orglett.8b00316. Epub 2018 Mar 14.

CuI-Mediated Synthesis of Sulfonyl Benzofuran-3-ones and Chroman-4-ones.

Author information

Department of Medicinal and Applied Chemistry , Kaohsiung Medical University , Kaohsiung 807 , Taiwan.
Department of Medical Research , Kaohsiung Medical University Hospital , Kaohsiung 807 , Taiwan.


A concise, one-pot synthesis of sulfonyl benzofuran-3-ones and chroman-4-ones from α-sulfonyl o-hydroxyacetophenones is described, using a combination of K2CO3, CuI, and dimethylsulfoxide (DMSO). This annulation protocol generates one carbon-oxygen (C-O) bond and one carbon-carbon (C-C) bond in a highly efficient manner.

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center