Format

Send to

Choose Destination
Clin Transl Oncol. 2018 Sep;20(9):1109-1116. doi: 10.1007/s12094-018-1839-y. Epub 2018 Mar 13.

Circular RNAs and exosomes in cancer: a mysterious connection.

Hou J1,2, Jiang W3, Zhu L1,2, Zhong S4, Zhang H5, Li J6, Zhou S7, Yang S1,2, He Y1,2, Wang D2, Chen X2, Deng F1,2, Zhang Q1,2, Wang J1,2, Hu J4, Zhang W8, Ding L8, Zhao J9, Tang J10,11.

Author information

1
The First Clinical School of Nanjing Medical University, Nanjing, 210029, People's Republic of China.
2
Department of General Surgery, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing City, 210029, Jiangsu Province, People's Republic of China.
3
State Key Laboratory of Reproductive Medicine, Nanjing, 210029, People's Republic of China.
4
Center of Clinical Laboratory Science, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, 210009, China.
5
Department of General Surgery, Zhong Da Hospital Southeast University, Nanjing, 210029, People's Republic of China.
6
Department of General Surgery, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, 210009, China.
7
Nanjing University of Chinese Medicine-Xianlin Campus, Nanjing, 210029, People's Republic of China.
8
Jiangsu Province Hospital, Nanjing, 210029, People's Republic of China.
9
Center of Clinical Laboratory Science, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, 210009, China. jhzhao2838@sina.com.
10
The First Clinical School of Nanjing Medical University, Nanjing, 210029, People's Republic of China. jhtang@njmu.edu.cn.
11
Department of General Surgery, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing City, 210029, Jiangsu Province, People's Republic of China. jhtang@njmu.edu.cn.

Abstract

Circular RNAs (CircRNAs) are a type of non-coding RNAs (NcRNAs) with a closed annular structure. Until next-generation sequencing (NGS) is developed, the misunderstanding of circRNAs 'splicing error' has changed, and the mysterious veil of circRNAs has been revealed. NGS provides an approach to investigate circRNAs. Many scholars point out that circRNAs may play an important role in many diseases, especially cancer. At the same time, exosomes, as a kind of extracellular vesicles loaded with many contents, are a hotspot in recent years. They can act as 'messengers' between cells, especially in cancer. Lately, it is interesting circRNAs are enriched and stable in exosomes, also called exo-circRNAs, and there have been several articles on circRNAs associated with exosomes. In this review, we summarize the characteristics of circRNAs, especially its main functions. Then, we briefly introduce exosomes and their function in cancer. Finally, the known relation between circRNAs and exosomes is discussed. With further researches, exo-circRNAs may be a novel pathway for cancer diagnosis and targeted therapy.

KEYWORDS:

Cancer; CircRNAs; Circular RNAs; Exosomes; Extracellular vesicles; Non-coding RNAs

PMID:
29536331
DOI:
10.1007/s12094-018-1839-y
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center