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Acta Neurol Belg. 2018 Jun;118(2):161-168. doi: 10.1007/s13760-018-0905-0. Epub 2018 Mar 13.

A Belgian consensus protocol for autologous hematopoietic stem cell transplantation in multiple sclerosis.

Author information

1
Department of Neurology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. laureysg@hotmail.com.
2
Department of Neurology, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.
3
Department of Neurology, AZ Sint Jan Brugge Oostende, Ruddershove 10, 8000, Brugge, Belgium.
4
Department of Hematology, AZ Sint Jan Brugge Oostende, Ruddershove 10, 8000, Brugge, Belgium.
5
Department of Neurology, Center for Neurosciences, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
6
Department of Hematology, UZ Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.
7
Department of Neurology, UZ Leuven, Herestraat 49, 3000, Louvain, Belgium.
8
Department of Hematology, UZ Leuven, Herestraat 49, 3000, Louvain, Belgium.
9
Unité de neuroimmunologie, Service de Neurologie, Hôpital Erasme-Université Libre de Bruxelles, Brussels, Belgium.
10
Department of Hematology, Hôpital Erasme-Université Libre de Bruxelles, Brussels, Belgium.
11
Department of Neurology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Belgium.
12
Department of Hematology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Belgium.
13
Department of Neurology, University Hospital of Liege, Rue Grandfosse 31-33, 4130, Esneux, Belgium.
14
Department of Hematology, University of Liège, CHU Sart Tilman, 4000, Liège, Belgium.
15
Biomedical Institute, Hasselt University and Rehabilitation and MS-Centre Overpelt, Agoralaan Gebouw A, 3590, Diepenbeek, Belgium.
16
Department of Hematology, Jessa Ziekenhuis, Stadsomvaart 11, 3500, Hasselt, Belgium.
17
Department of Hematology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
18
Department of Hematology, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.

Abstract

Multiple sclerosis is considered to be an immune mediated inflammatory disorder of the central nervous system. It mainly affects young, socioeconomic active patients. Although our armamentarium for this disease has significantly evolved in recent years some patients remain refractory to conventional therapies. In these cases, autologous hematopoietic stem cell transplantation can be considered as a therapeutic option. Decreasing morbidity, mortality, and increasing patient awareness have led to rising inquiry by our patients about this treatment option. With the aim of a standardized protocol and data registration, a Belgian working party on stem cell therapy in multiple sclerosis was established. In this paper, we report the consensus protocol of this working party on autologous hematopoietic stem cell transplantation in multiple sclerosis.

KEYWORDS:

Autologous hematopoietic stem cell transplantation; Consensus Paper; Multiple sclerosis

PMID:
29536270
DOI:
10.1007/s13760-018-0905-0
[Indexed for MEDLINE]
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