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Semin Fetal Neonatal Med. 2018 Aug;23(4):278-284. doi: 10.1016/j.siny.2018.03.002. Epub 2018 Mar 7.

International perspective on management of a patent ductus arteriosus: Lessons learned.

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Monash Newborn, Monash Children's Hospital, Melbourne, Australia; Department of Pediatrics, Monash University, Melbourne, Australia. Electronic address:
Department of Paediatrics, University of Toronto, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; Division of Neonatology, Hospital for Sick Children, Toronto, Canada.


Whereas association between a patent ductus arteriosus (PDA) and neonatal morbidities has been well described, consensus has not been reached on whether the relationship is causal, on benefit of (or lack of) treatment, on factors guiding the 'need to treat', and on treatment strategies. Trials to date have primarily focused on the narrow outcome of successful ductal closure. Evidence from several retrospective studies has suggested that management may be modified with increased use of conservative treatment. A paradigm shift has resulted in decreased use of treatments to close the PDA in some centres. This approach cites the lack of demonstrable improvement in short- and long-term respiratory and neurodevelopmental outcomes as an argument. This article reviews current understanding of the wide variation in practice at either institutional, regional, national, or international level. It discusses the potential contributors to variability in diagnostic ascertainment and therapeutic intervention.


Consensus; Duct ligation; Global variation; Medical therapy; Patent ductus arteriosus

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