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Trends Microbiol. 2018 Sep;26(9):781-793. doi: 10.1016/j.tim.2018.02.007. Epub 2018 Mar 10.

Within-Host Evolution of Human Influenza Virus.

Author information

1
Department of Genome Sciences, University of Washington, Seattle, WA, USA; Division of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
2
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
3
Department of Genome Sciences, University of Washington, Seattle, WA, USA; Division of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: jbloom@fredhutch.org.

Abstract

The rapid global evolution of influenza virus begins with mutations that arise de novo in individual infections, but little is known about how evolution occurs within hosts. We review recent progress in understanding how and why influenza viruses evolve within human hosts. Advances in deep sequencing make it possible to measure within-host genetic diversity in both acute and chronic influenza infections. Factors like antigenic selection, antiviral treatment, tissue specificity, spatial structure, and multiplicity of infection may affect how influenza viruses evolve within human hosts. Studies of within-host evolution can contribute to our understanding of the evolutionary and epidemiological factors that shape influenza virus's global evolution.

KEYWORDS:

deep sequencing; evolution; influenza; within-host

PMID:
29534854
PMCID:
PMC6097882
[Available on 2019-09-01]
DOI:
10.1016/j.tim.2018.02.007
[Indexed for MEDLINE]

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