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Dev Cell. 2018 Mar 12;44(5):535-537. doi: 10.1016/j.devcel.2018.02.018.

APC Moonlights to Prevent Wnt Signalosome Assembly.

Author information

1
The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: ian.mcgough@crick.ac.uk.
2
The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: jp.vincent@crick.ac.uk.

Abstract

The scaffold protein APC has a well-known function in ensuring β-catenin destruction. In this issue of Developmental Cell, Saito-Diaz et al. (2018) uncover another role for APC in Wnt signaling: to prevent clathrin-dependent signalosome formation in the absence of ligand.

PMID:
29533767
PMCID:
PMC5861992
DOI:
10.1016/j.devcel.2018.02.018
[Indexed for MEDLINE]
Free PMC Article

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