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Nat Prod Res. 2018 Mar 13:1-7. doi: 10.1080/14786419.2018.1448811. [Epub ahead of print]

Bioactive sesquiterpenoids and steroids from the resinous exudates of Commiphora myrrha.

Ge CY1,2, Zhang JL1,2.

Author information

1
a School of Pharmacy , Jiangsu Food and Pharmaceutical Science College , Huai'an, Jiangsu , China.
2
b Jiangsu Protein Drug Engineering Lab , Huai'an, Jiangsu , China.

Abstract

Chemical investigation of the resinous exudates of Commiphora myrrha has led to the isolation of four sesquiterpenes (1a/1b, 2, and 3), including one pair of new sesquiterpene enantiomers (1a/1b), one new racemic mixture 2, and two steroids (4 and 5). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1a/1b were determined by CD analysis. The antimigratory potential of compounds 1-5 were evaluated and compound 3 was found to inhibit human hepatocellular liver carcinoma HepG2 cell migration in dose-dependent manner.

KEYWORDS:

Commiphora myrrha; antimigratory activity; sesquiterpene; steroids

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