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Br J Cancer. 2018 Apr;118(7):1020-1027. doi: 10.1038/s41416-018-0009-x. Epub 2018 Mar 13.

Influence of obesity-related risk factors in the aetiology of glioma.

Author information

1
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
2
Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
3
Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MI, 55905, USA.
4
Section of Epidemiology and Population Sciences, Department of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
5
School of Public Health, Yale University, New Haven, CT, 06510, USA.
6
Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.
7
Department of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, GA, 30303, USA.
8
Duke Cancer Institute, Duke University Medical Center, Durham, NC, 27710, USA.
9
Cancer Control and Prevention Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, 27710, USA.
10
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10017, USA.
11
Departments of Neurology and Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
12
Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK.
13
Department of Neurosurgery, University of Bonn Medical Center, Sigmund-Freud-Str. 25, Bonn, 53105, Germany.
14
Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, 4031, Switzerland.
15
Department of Genomics, Life & Brain Center, University of Bonn, Bonn, 53127, Germany.
16
Institute of Human Genetics, University of Bonn School of Medicine and University Hospital Bonn, Bonn, 53127, Germany.
17
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, 45147, Germany.
18
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
19
Danish Cancer Society Research Center, Survivorship, Danish Cancer Society, Copenhagen, 2100, Denmark.
20
Oncology Clinic, Finsen Centre, Rigshospitalet, University of Copenhagen, Copenhagen, 2100, Denmark.
21
Department of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MI, 55905, USA.
22
Department of Radiation Sciences, Umeå University, Umeå, 901 87, Sweden.
23
Department of Neurological Surgery, School of Medicine, University of California, San Francisco, CA, 94143, USA.
24
Institute of Human Genetics, University of California, San Franciso, CA, 94143, USA.
25
Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS, U1127, UMR 7225, ICM, Paris, 75013, France.
26
AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie 2-Mazarin, Paris, 75013, France.
27
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK. richard.houlston@icr.ac.uk.
28
Division of Molecular Pathology, The Institute of Cancer Research, London, SW7 3RP, UK. richard.houlston@icr.ac.uk.

Abstract

BACKGROUND:

Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation.

METHODS:

Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship.

RESULTS:

No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours.

CONCLUSIONS:

This study provides no evidence to implicate obesity-related factors as causes of glioma.

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