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BMC Cancer. 2018 Mar 12;18(1):280. doi: 10.1186/s12885-018-4182-3.

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project.

Author information

1
Universidad de Cantabria - IDIVAL, Santander, Spain.
2
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
3
Universidad de Granada - ibs.Granada, Granada, Spain.
4
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avenida Monforte de Lemos 5, 28029, Madrid, Spain.
5
Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro (IDIPHIM), Manuel de Falla 1, 28222, Madrid, Spain.
6
Breast Cancer Early Detection Programme, Basque Health Service-Osakidetza, San Sebastian, Spain.
7
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
8
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
9
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
10
Universidad de León, León, Spain.
11
Public Health Institute of Navarra, IdiSNA, Pamplona, Spain.
12
IUOPA, Universidad de Oviedo, Asturias, Spain.
13
Public Health Division of Gipuzkoa, BioDonostia Research Health Institute, San Sebastian, Spain.
14
IDIBELL-Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain.
15
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
16
Health Services Research on Chronic Patients Network, REDISSEC, Valencia, Spain.
17
Universidad de Cantabria - IDIVAL, Santander, Spain. javier.llorca@unican.es.
18
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. javier.llorca@unican.es.
19
Facultad de Medicina, Universidad de Cantabria, Avda. Herrera Oria s/n, 39011, Santander, Spain. javier.llorca@unican.es.

Abstract

BACKGROUND:

Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship.

METHODS:

One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression.

RESULTS:

Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced.

CONCLUSIONS:

The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.

KEYWORDS:

Breast cancer; Genetic interactions; Reproductive factors

PMID:
29530003
PMCID:
PMC5848450
DOI:
10.1186/s12885-018-4182-3
[Indexed for MEDLINE]
Free PMC Article

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