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PLoS One. 2018 Mar 12;13(3):e0193288. doi: 10.1371/journal.pone.0193288. eCollection 2018.

Influence of dialysis membrane composition on plasma bisphenol A levels during online hemodiafiltration.

Author information

1
Renal, Vascular and Diabetes Laboratory, IIS-Fundación Jimenez Diaz UAM, Madrid, Spain.
2
Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain.
3
Division of Nephrology, Hospital Universitario de Burgos, Burgos, Spain.
4
Department of Biostatistics and Epidemiology, IIS-Fundación Jimenez Diaz UAM, Madrid, Spain.
5
Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz UAM, Madrid, Spain.
6
Department of Medicine, UAM, Madrid, Spain.
7
Kidney Research Network (REDINREN), Madrid, Spain.

Abstract

INTRODUCTION:

Bisphenol A (BPA) is an ubiquitous environmental toxin that is also found in dialyzers. Online hemodiafiltration (OL-HDF) more efficiently clears high molecular weight molecules, and this may improve BPA clearance. However, the BPA contents of dialysis membranes may be a source of BPA loading during OL-HDF.

METHODS:

A prospective study assessed plasma BPA levels in OL-HDF patients using BPA-free (polynephron) or BPA-containing (polysulfone) dialyzers in a crossover design with two arms, after a run-in OL-HDF period of at least 6 months with the same membrane: 31 patients on polynephron at baseline were switched to polysulfone membranes for 3 months (polynephron-to-polysulfone) and 29 patients on polysulfone were switched to polynephron for 3 months (polysulfone-to-polynephron).

RESULTS:

After a run-in OL-HDF period of at least 6 months with the same membrane, baseline pre-dialysis BPA was lower in patients on polynephron (8.79±7.97 ng/ml) than in those on polysulfone (23.42±20.38 ng/mL, p<0.01), but still higher than in healthy controls (<2 ng/mL). After 3 months of polynephron-to-polysulfone switch, BPA was unchanged (8.98±7.88 to 11.14±15.98 ng/mL, ns) while it decreased on the polysulfone-to-polynephron group (23.42±20.38 to 11.41±12.38 ng/mL, p<0.01).

CONCLUSION:

OL-HDF for 3 months with BPA-free dialyzer membranes was associated to a significant decrease in predialysis BPA levels when compared to baseline BPA levels while on a BPA-containing membrane.

PMID:
29529055
PMCID:
PMC5846770
DOI:
10.1371/journal.pone.0193288
[Indexed for MEDLINE]
Free PMC Article

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