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J Infect Dis. 2018 May 25;217(12):1883-1888. doi: 10.1093/infdis/jiy131.

No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients.

Author information

1
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Switzerland.
2
Institute of Medical Virology, University of Zurich, Switzerland.
3
Department of Infectious Diseases and Hospital Hygiene, University Hospital Basel, University of Basel, Switzerland.
4
Department of Infectious Diseases, Bern University Hospital, University of Bern, Switzerland.
5
Division of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Switzerland.
6
Division of Infectious Diseases and Hospital Epidemiology, Kantonal Hospital St Gallen, Switzerland.

Abstract

Pegylated interferon-alpha (pIFN-α) is suggested to lower human immunodeficiency virus type-1 (HIV-1) DNA load in antiretroviral therapy (ART)-treated patients. We studied kinetics of HIV-1 DNA levels in 40 HIV-1/hepatitis C virus (HCV) coinfected patients, treated with pIFN-α for HCV and categorized into 3 groups according to start of ART: chronic HIV-1 infection (n = 22), acute HIV-1 infection (n = 8), no-ART (n = 10). Total HIV-1 DNA levels in 247 peripheral blood mononuclear cell samples were stable before, during, and after pIFN-α treatment in all groups. Our results question the benefit of pIFN-α as an immunotherapeutic agent for reducing the HIV-1 reservoir.

PMID:
29528417
DOI:
10.1093/infdis/jiy131

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