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J Rheumatol. 1987 Feb;14(1):19-22.

Effect of divided daily dose prednisone therapy on circulating T cell subsets.


Prednisone induced reductions in the circulating human T cell population follow a characteristic time curve which persists even after a single daily dose of oral prednisone has been administered many times. If prednisone doses are administered every 6 h, so that a dose occurs near the point of maximum response from a previous dose (4-6 h), the reduction in size of the circulating T cell population will persist so long as administration of prednisone continues. A chronically depressed ratio of OKT4+ to OKT8+ cells is observed in most patients when as little as 2.5 mg of prednisone is administered every 6 h.

[Indexed for MEDLINE]

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