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Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13636.

Muscle phenotype is related to motor unit behavior of the vastus lateralis during maximal isometric contractions.

Author information

1
Applied Neuromuscular Physiology Laboratory, Oklahoma State University, Stillwater, Oklahoma.
2
Molecular and Applied Sciences Laboratory, Auburn University, Auburn, Alabama.
3
Department of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine - Auburn Campus, Auburn, Alabama.

Abstract

Previous investigations have reported a relationship between skeletal muscle phenotype and motor unit (MU) firing parameters during submaximal contractions. The purpose of the current investigation, however, was to examine the relationships between motor unit firing behavior during a maximal voluntary contraction, Myosin Heavy Chain (MHC) isoform content, and various molecular neuromuscular targets of the vastus lateralis (VL) muscle in resistance-trained men. Ten resistance-trained males completed a trapezoidal ramp contraction up to 100% of their maximal voluntary isometric strength (MVIC). Surface electromyography was recorded from the VL using a multichannel electrode array and decomposed to examine the firing characteristics of individual MUs. A skeletal muscle biopsy of the VL was also collected from each subject. Regression analyses were performed to identify relationships between type II fiber area and the slopes and/or intercepts of the mean firing rate (FRMEAN ) versus recruitment threshold (RT), max firing rate (FRMAX ) versus RT, and RT versus MU action potential amplitude (MUAPPP ) relationships. There were significant inverse relationships between type II fiber area and the y-intercept of the FR versus RT relationship (P < 0.05). Additionally, strong relationships (r > 0.5) were found between type II fiber area and FRMEAN versus RT slope and RT versus MUAPPP slope and intercept. These data further support the hypothesis that skeletal muscle phenotype is related to MU behavior during isometric contraction. However, our data, in concert with previous investigations, may suggest that these relationships are influenced by the intensity of the contraction.

KEYWORDS:

motor unit firing rates; myosin heavy chain; sEMG decomposition

PMID:
29527830
PMCID:
PMC5845862
DOI:
10.14814/phy2.13636
[Indexed for MEDLINE]
Free PMC Article

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