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Chem Commun (Camb). 2018 Mar 28;54(25):3142-3145. doi: 10.1039/c8cc00931g. Epub 2018 Mar 12.

A black phosphorus nanosheet-based siRNA delivery system for synergistic photothermal and gene therapy.

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Key Laboratory for Analytical Science of Food Safety and Biology of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China.
College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, P. R. China.


Gene therapy with small interfering RNA (siRNA) has been proved to be a promising technology to treat various diseases by hampering the production of target proteins. However, developing a delivery system that has high efficiency in transporting siRNA without obvious side effects remains a challenge. Herein, we designed a new survivin siRNA delivery system based on polyethyleneimine functionalized black phosphorus (BP) nanosheets which could suppress tumor growth by silencing survivin expression. Combined with the photothermal properties of the BP nanosheets, the presented delivery system shows excellent therapy efficiency for tumors. Therefore, the BP-based delivery system would be a promising tool for future clinical applications.

[Indexed for MEDLINE]

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