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Neuroimage Clin. 2017 Dec 24;17:935-942. doi: 10.1016/j.nicl.2017.12.034. eCollection 2018.

Dysfunctional frontal lobe activity during inhibitory tasks in individuals with childhood trauma: An event-related potential study.

Kim S1,2, Kim JS1,3, Jin MJ1,4, Im CH2, Lee SH1,5.

Author information

1
Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Republic of Korea.
2
Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea.
3
Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, 31151, Republic of Korea.
4
Department of Psychology, Chung-Ang University, Seoul, Republic of Korea.
5
Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Republic of Korea.

Abstract

Background:

Individuals who experience childhood trauma are vulnerable to various psychological and behavioral problems throughout their lifetime. This study aimed to investigate whether individuals with childhood trauma show altered frontal lobe activity during response inhibition tasks.

Methods:

In total, 157 healthy individuals were recruited and instructed to perform a Go/Nogo task during electroencephalography recording. Source activities of N2 and P3 of Nogo event-related potentials (ERP) were analyzed. The Childhood Trauma Questionnaire (CTQ) and Barratt Impulsivity Scale (BIS) were applied. Individuals were divided into three groups based on their total CTQ score: low CTQ, middle CTQ, and high CTQ groups.

Results:

The high CTQ group exhibited significantly higher BIS scores than the low CTQ group. P3 amplitudes of the differences between Nogo and Go ERP waves exhibited higher mean values in the low CTQ than the high CTQ group, with trending effects. In Nogo-P3, the source activities of the right anterior cingulate cortex, bilateral medial frontal cortex (MFC), bilateral superior frontal gyrus (SFG), and right precentral gyrus were significantly lower in the high CTQ than the low CTQ group. Motor impulsivity showed a significant negative correlation with activities of the bilateral MFC and SFG in Nogo-P3 conditions.

Conclusions:

Our study revealed that individuals with childhood trauma have inhibitory failure and frontal lobe dysfunction in regions related to Nogo-P3.

KEYWORDS:

Childhood trauma; Frontal lobe dysfunction; Go/Nogo task; Inhibitory function; Source activity

PMID:
29527497
PMCID:
PMC5842757
DOI:
10.1016/j.nicl.2017.12.034
[Indexed for MEDLINE]
Free PMC Article

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