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Pain Res Manag. 2017;2017:9045608. doi: 10.1155/2017/9045608. Epub 2017 Dec 13.

Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model.

Author information

1
Department of Anesthesiology and Pain Medicine, Suryeoan Clinic, Busan, Republic of Korea.
2
Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Republic of Korea.
3
Department of Pathology, Kosin University College of Medicine, Busan, Republic of Korea.
4
Department of Anesthesiology and Pain Medicine, Ulsan University College of Medicine, Ulsan, Republic of Korea.

Abstract

Background:

Several studies have shown that dexmedetomidine (DXM), a selective α2-adrenoceptor agonist, also has neuroprotective effects. However, its effect on impaired peripheral nerve regeneration has not been studied.

Materials and Methods:

Forty-five Sprague-Dawley rats were randomly assigned to three groups: group 1 (control SHAM), group 2 (sciatic nerve injury + normal saline), and group 3 (sciatic nerve injury + DXM). The rats of group 3 were subdivided into the following three groups: DXM 0.5, 6, and 20 μg·kg-1 (groups 3A, 3B, and 3C, resp.). The sciatic nerve injury was assessed for nerve regeneration at 2 and 6 weeks.

Results:

There were no differences between groups 2 and 3 in their sciatic functional index (SFI) values or histological findings at 2 weeks postinjury. However, SFI differences were statistically significant at 6 weeks postinjury in group 3. The gross findings with H&E staining showed that the number of axons was higher in group 3 than in group 2. There was no histological difference according to the DXM concentration.

Conclusion:

The coincidental functional and histological assessment results of this study suggest that DXM for 6 weeks positively affects damaged peripheral nerves.

PMID:
29527118
PMCID:
PMC5745707
DOI:
10.1155/2017/9045608
[Indexed for MEDLINE]
Free PMC Article

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