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Bioorg Med Chem Lett. 2018 Apr 15;28(7):1252-1256. doi: 10.1016/j.bmcl.2018.01.004. Epub 2018 Jan 4.

Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum.

Author information

1
College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
2
School of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
3
College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
4
College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea. Electronic address: byhwang@chungbuk.ac.kr.

Abstract

Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1-3) along with four known compounds (4-7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Of these, compounds 4-7 dose-dependently inhibited the melanin production with the IC50 values ranging from 4 μM to 33 μM.

KEYWORDS:

Asclepiadaceae; Cynanchum atratum; Melanogenesis inhibitor; Pregnane glycosides; α-MSH

PMID:
29526485
DOI:
10.1016/j.bmcl.2018.01.004
[Indexed for MEDLINE]

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