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Clin Rheumatol. 2018 Jul;37(7):1763-1771. doi: 10.1007/s10067-018-4060-z. Epub 2018 Mar 10.

Evaluation of work disability in Japanese patients with rheumatoid arthritis: from the TOMORROW study.

Author information

1
Department of Orthopaedic Surgery, Shirahama Hamayu Hospital, 1447 Shirahamacho, Nishimurogun, Wakayama, 649-2211, Japan.
2
Search Institute for Bone and Arthritis Disease (SINBAD), Shirahama Foundation for Health and Welfare, 1447 Shirahamacho, Nishimurogun, Wakayama, 649-2211, Japan.
3
Center for Senile Degenerative Disorders (CSDD), Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
4
Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
5
Department of Orthopaedic Surgery, Shirahama Hamayu Hospital, 1447 Shirahamacho, Nishimurogun, Wakayama, 649-2211, Japan. tatsuya@med.osaka-cu.ac.jp.
6
Search Institute for Bone and Arthritis Disease (SINBAD), Shirahama Foundation for Health and Welfare, 1447 Shirahamacho, Nishimurogun, Wakayama, 649-2211, Japan. tatsuya@med.osaka-cu.ac.jp.
7
Center for Senile Degenerative Disorders (CSDD), Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan. tatsuya@med.osaka-cu.ac.jp.

Abstract

To evaluate work disability and associated factors in patients with rheumatoid arthritis (RA) who participated in the TOMORROW study, a 10-year cohort study in Japan. Subjects in this cross-sectional analysis comprised 191 RA patients and 191 age- and sex-matched non-RA individuals. Work-related outcomes were measured using the Work Productivity and Activity Impairment questionnaire by employment status (full-time worker (FTW), employed ≥ 35 h/week; part-time worker (PTW), < 35 h/week; home worker (HW), non-employed). In addition, we assessed the EuroQol-5 Dimensions (EQ-5D) and Health Assessment Questionnaire (HAQ) to evaluate quality of life and activities of daily living. No significant differences were evident between groups in percentages of participants in each employment status (p = 0.11), percentages of absenteeism (FTW, p = 1.00; PTW, p = 0.29), presenteeism (FTW, p = 0.23; PTW, p = 0.54), overall work impairment (FTW, p = 0.23; PTW, p = 0.73), or percentage of activity impairment (AI) (FTW, p = 0.62; PTW, p = 0.60). In the HW group, percentage of AI was higher in RA patients than that in non-RA patients (p < 0.01). Among RA patients, HW showed lower EQ-5D and higher HAQ than FTW or PTW (p < 0.001 each). Higher disease activity was observed in HW than FTW (p < 0.01). In terms of the effect of biological disease-modifying anti-rheumatic drugs, no significant differences in work-related outcomes, health status, or daily activity were evident between users and non-users. No significant differences in employment status or work impairment were seen between RA and non-RA groups among paid workers. HW with RA showed more impaired daily activity and higher disease activity compared to working RA patients.

TRIAL REGISTRATION:

University Hospital Medical Information Network Clinical Trials Registry: UMIN000003876 . Registered 1 Jun 2010.

KEYWORDS:

Absenteeism; Disease activity; Overall work impairment; Presenteeism; Rheumatoid arthritis; Work disability

PMID:
29525846
DOI:
10.1007/s10067-018-4060-z
[Indexed for MEDLINE]

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