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Trends Microbiol. 2018 Sep;26(9):794-808. doi: 10.1016/j.tim.2018.02.006. Epub 2018 Mar 7.

Towards Understanding MCR-like Colistin Resistance.

Author information

1
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou 510642, China; These authors contributed equally to this work.
2
Department of Medical Microbiology & Parasitology, Zhejiang University School of Medicine, Hangzhou 310058, China; These authors contributed equally to this work.
3
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou 510642, China. Electronic address: lyh@scau.edu.cn.
4
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou 510642, China; Department of Medical Microbiology & Parasitology, Zhejiang University School of Medicine, Hangzhou 310058, China; College of Animal Sciences, Zhejiang University, Hangzhou 310058, China; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou 510642, China. Electronic address: fengyj@zju.edu.cn.

Abstract

Antibiotic resistance has become a global public health priority. Polymyxins, a family of cationic polypeptide antibiotics, act as a final line of refuge against severe infections by Gram-negative pathogens with pan-drug resistance. Unfortunately, this last-resort antibiotic has been challenged by the emergence and global spread of mobilized colistin resistance determinants (mcr). Given the fact that it has triggered extensive concerns worldwide, we present here an updated view of MCR-like colistin resistance. These studies provide a basic framework for understanding the molecular epidemiology and resistance mechanism of MCR-like genes. However, further large-scale epidemiology and functional studies are urgently needed to better understand the biology of this clinically important antibiotic resistance.

KEYWORDS:

MCR-1; MCR-2; biochemical mechanism; colistin resistance; genetic determinants; polymyxin

PMID:
29525421
DOI:
10.1016/j.tim.2018.02.006
[Indexed for MEDLINE]

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