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Bioorg Med Chem Lett. 2018 Apr 15;28(7):1207-1210. doi: 10.1016/j.bmcl.2018.02.050. Epub 2018 Feb 27.

Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui.

Author information

1
College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Gyeonggi-do 10326, Republic of Korea.
2
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
3
College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Gyeonggi-do 10326, Republic of Korea. Electronic address: f2744@dongguk.edu.

Abstract

As part of our ongoing search for anti-inflammatory compounds from higher plants, we isolated and elucidated two new diterpenoid glycosides, kansuingol A (1) and kansuingol B (2), from the roots of Euphorbia kansui. These structures were elucidated by extensive spectroscopic methods such as NMR and MS. Compounds were assessed for their IL-6 production inhibitory activity in PMA + A23187-stimulated HMC-1 cells. As a result, compounds 1 and 2 exerted inhibitory activities in the production of IL-6 with IC50 values of 2.96, and 1.94 μM, respectively. Further, kansuingol A (1) decreased mRNA expressions of TNF-α and IL-6.

KEYWORDS:

Anti-inflammatory; Diterpenoid; Euphorbia kansui; IL-6; Kansuingol A; Kansuingol B; TNF-α

PMID:
29525220
DOI:
10.1016/j.bmcl.2018.02.050
[Indexed for MEDLINE]

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