Format

Send to

Choose Destination
Environ Pollut. 2018 Jun;237:559-568. doi: 10.1016/j.envpol.2018.02.065. Epub 2018 Mar 15.

Risk of breast cancer and residential proximity to industrial installations: New findings from a multicase-control study (MCC-Spain).

Author information

1
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos 5, 28029, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain. Electronic address: jgarcia@isciii.es.
2
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos 5, 28029, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain. Electronic address: vicarvajal@isciii.es.
3
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos 5, 28029, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain. Electronic address: bperez@isciii.es.
4
Research Group on Gene-Environment Interactions and Health, Institute of Biomedicine (IBIOMED), University of León, Campus Vegazana s/n, 24071, León, Spain. Electronic address: ajmolt@unileon.es.
5
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain; Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Facultad de Medicina, Planta 7, Campus de El Cristo B, 33006, Oviedo, Spain. Electronic address: atardon@uniovi.es.
6
Centro de Investigación en Salud y Medio Ambiente (CYSMA), Universidad de Huelva, Campus Universitario de El Carmen, 21071, Huelva, Spain. Electronic address: alguacil@dbasp.uhu.es.
7
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain; Instituto de Salud Pública de Navarra, IdiSNA - Navarra Institute for Health Research, C/Leyre 15, 31003, Pamplona, Spain. Electronic address: me.ardanaz.aicua@cfnavarra.es.
8
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain; ISGlobal, Carrer del Doctor Aiguader 88, 08003, Barcelona, Spain; Pompeu Fabra University (UPF), Plaça de la Mercè 10-12, 08002, Barcelona, Spain. Electronic address: cristina.ocallaghan@isglobal.org.
9
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain; Breast Cancer Screening Program, Osakidetza - Basque Health Service, Sancho el Sabio 35, 20010 San Sebastián, Spain. Electronic address: JONEMIREN.ALTZIBARAROTZENA@osakidetza.eus.
10
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain; Universidad de Cantabria - IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011 Santander, Spain. Electronic address: ines.gomez@unican.es.
11
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain; Cancer Prevention and Control Program, Catalan Institute of Oncology, Avinguda de la Granvia de l'Hospitalet 199-203, 08908, Hospitalet de Llobregat, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Gran Via de les Corts Catalanes 585, 08007, Barcelona, Spain; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Gran Via de l'Hospitalet 199, 08908, Hospitalet de Llobregat, Spain. Electronic address: v.moreno@iconcologia.net.
12
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain; Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana FISABIO-Salud Pública - Foundation for the Promotion of Health and Biomedical Research of Valencian Region (FISABIO), Avda. de Catalunya 21, 46020, Valencia, Spain. Electronic address: peiro_ros@gva.es.
13
Epidemiology Unit and Girona Cancer Registry (UERCG), Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology (ICO), Girona Biomedical Research Institute (IDIBGI), University of Girona, Carrer del Sol 15, 17004 Girona, Spain. Electronic address: rmarcos@iconcologia.net.
14
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain; ISGlobal, Carrer del Doctor Aiguader 88, 08003, Barcelona, Spain; Pompeu Fabra University (UPF), Plaça de la Mercè 10-12, 08002, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Dr. Aiguader 88, 08003, Barcelona, Spain. Electronic address: manolis.kogevinas@isglobal.org.
15
Epidemiology Section, Public Health Division, Department of Health of Madrid, C/ San Martín de Porres 6, 28035, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain. Electronic address: nuria.aragones@salud.madrid.org.
16
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos 5, 28029, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain. Electronic address: glabente@isciii.es.
17
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos 5, 28029, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública - CIBERESP), Avda. Monforte de Lemos 3-5, Madrid, Spain. Electronic address: mpollan@isciii.es.

Abstract

Breast cancer is the most frequent tumor in women worldwide, although well-established risk factors account for 53%-55% of cases. Therefore, other risk factors, including environmental exposures, may explain the remaining variation. Our objective was to assess the relationship between risk of breast cancer and residential proximity to industries, according to categories of industrial groups and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Using the current residence of cases and controls, this study was restricted to small administrative divisions, including both breast cancer cases (452) and controls (1511) in the 10 geographical areas recruiting breast cancer cases. Distances were calculated from the respective woman's residences to the 116 industries located in the study area. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (between 1 km and 3 km) to industrial plants, adjusting for matching variables and other confounders. Excess risk (OR; 95%CI) of breast cancer was found near industries overall (1.30; 1.00-1.69 at 3 km), particularly organic chemical industry (2.12; 1.20-3.76 at 2.5 km), food/beverage sector (1.87; 1.26-2.78 at 3 km), ceramic (4.71; 1.62-13.66 at 1.5 km), surface treatment with organic solvents (2.00; 1.23-3.24 at 3 km), and surface treatment of plastic and metals (1.51; 1.06-2.14 at 3 km). By pollutants, the excess risk (OR; 95%CI) was detected near industries releasing pesticides (2.09; 1.14-3.82 at 2 km), and dichloromethane (2.09; 1.28-3.40 at 3 km). Our results suggest a possible increased risk of breast cancer in women living near specific industrial plants and support the need for more detailed exposure assessment of certain agents released by these plants.

KEYWORDS:

Breast cancer; Case-control study; Endocrine disrupting chemicals; Industrial pollution; Pesticides; Residential proximity

PMID:
29524878
DOI:
10.1016/j.envpol.2018.02.065
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center