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J Pediatr Surg. 2018 May;53(5):898-904. doi: 10.1016/j.jpedsurg.2018.02.012. Epub 2018 Feb 7.

The glucagon like peptide-2 'axis': Capacity for production and response following intestinal resection or repair of gastroschisis in infants.

Author information

1
Department of Pediatric Surgery, Sidra Medical and Research Center, Doha, Qatar; Children's Hospital Intestinal Rehabilitation Program, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada. Electronic address: dsigalet@sidra.org.
2
Children's Hospital Intestinal Rehabilitation Program, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada.
3
Department of Pediatric Surgery, Sidra Medical and Research Center, Doha, Qatar; Children's Hospital Intestinal Rehabilitation Program, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada.
4
NNF Center for Basic Metabolic Research, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Abstract

PURPOSE:

This study investigates the relationship between the enteric hormone glucagon-like peptide 2 (GLP-2) production, sensitivity, and intestinal adaptation in infants following resection or repair of gastroschisis.

METHODS:

With IRB approval (UCalgary #10656), consent was obtained from families of infants undergoing surgery for prospective monitoring of nutritional status, GLP-2 levels, and where possible, tissue sampling.

RESULTS:

Infants who adapted and weaned from parenteral nutrition (PN) had increased GLP-2 (86±32) n=24 vs. controls: 45±20 n=10 and vs. patients on prolonged PN: 42±6 pM, n=10). This was maintained to one year: weaned patients: 72±49 vs. non-weaned: 35±15 pM (p<0.05). Infants with gastroschisis (n=33) had decreased GLP-2 levels until enteral function was achieved and then became elevated: (21±15 with first feeding vs. 102±60 at full feeds and 60±19 pM at one year). There were no changes in the density or distribution of GLP-2 producing L-cells related to gestational age, nor in the expression of the GLP-2 receptor.

CONCLUSION:

GLP-2 levels correlate with intestinal adaptation in infants, and with recovery of intestinal function in gastroschisis. GLP-2 productive capacity (L-cell expression) and GLP-2 receptor expression do not vary with maturity. The findings support a role for GLP-2 in regulating intestinal function. Further study is suggested.

KEYWORDS:

Enteroendocrine; Intestinal failure; L-cell; Short bowel

PMID:
29523359
DOI:
10.1016/j.jpedsurg.2018.02.012
[Indexed for MEDLINE]

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