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Int J Gynecol Pathol. 2019 Jan;38 Suppl 1:S114-S122. doi: 10.1097/PGP.0000000000000496.

International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines From the Special Techniques and Ancillary Studies Group.

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MD Anderson Cancer Center, Houston, Texas (R.B., A.Y., A.M.) University of Michigan Medical School, Ann Arbor, Michigan (K.R.C.) Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania (K.C.) Bergonie Institute, Bordeaux, France (S.C.) The Ottawa Hospital, University of Ottawa, Ottawa (B.D.) Toronto General Hospital, Toronto (P.S., B.C.), Ontario Department of Pathology, University of Calgary, Calgary, Alberta (M.K.), Canada Edinburgh Cancer Research Centre, Edinburgh (S.H.) Belfast Health and Social Care Trust, Belfast (W.G.M.), UK Brigham and Women's Hospital (B.H., B.J.Q.) Massachusetts General Hospital, Harvard University (E.O.), Boston, Massachusetts Yale New Haven Hospital, New Haven, Connecticut (P.H., V.P.) Department of Pathology, University of Hong Kong, Hong Kong, China (P.I.) Department of Pathology, Medical University of Graz, Graz, Austria (S.L.) Bellvitge University Hospital, IDIBELL, Barcelona (A.V., X.M.G.) Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLLEIDA, Lleida (X.M.G.), CIBERONC, Spain Weill Cornell Medical College, New York, New York (L.H.E.) Stanford University Medical Center, Stanford, California (T.A.L.) Johns Hopkins University School of Medicine, Baltimore, Maryland (I.M.S.).


The aim of this article is to propose guidelines and recommendations in problematic areas in pathologic reporting of endometrial carcinoma (EC) regarding special techniques and ancillary studies. An organizing committee designed a comprehensive survey with different questions related to pathologic features, diagnosis, and prognosis of EC that was sent to all members of the International Society of Gynecological Pathologists. The special techniques/ancillary studies group received 4 different questions to be addressed. Five members of the group reviewed the literature and came up with recommendations and an accompanying text which were discussed and agreed upon by all members of the group. Twelve different recommendations are made. They address the value of immunohistochemistry, ploidy, and molecular analysis for assessing prognosis in EC, the value of steroid hormone receptor analysis to predict response to hormone therapy, and parameters regarding applying immunohistochemistry and molecular tests for assessing mismatch deficiency in EC.

[Indexed for MEDLINE]
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