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Curr Med Chem. 2018 Mar 6. doi: 10.2174/0929867325666180307114332. [Epub ahead of print]

Neurodegenerative Process Linking the Eye and the Brain.

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Ophthalmology Unit, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome. Italy.
University of Rome Tor Vergata Via Montpellier - Department of Experimental Medicine and Surgery Rome. Italy.
Neuroradiology Unit, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome. Italy.


Recent literature agrees that neurodegenerative processes involve both the retina and the central nervous system, which are two strictly related anatomical structures. However, the causal mechanisms of this dual involvement are still uncertain. To date, anterograde transynaptic neurodegeneration, triggered by retinal ganglion cells' death, and retrograde transynaptic neurodegeneration, induced by neurodegenerative processes of the central nervous system, have been considered the major possible causal mechanisms. The development of novel neuroimaging techniques has recently supported both the study of the central stations of the visual pathway as well as the study of the retina which is a possible open window to the central nervous system.


Alzheimer; MRI; Multiple Sclerosis; Parkinson; central nervous system; eye; glaucoma; neurodegeneration

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