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Transbound Emerg Dis. 2018 Jun;65(3):607-613. doi: 10.1111/tbed.12853. Epub 2018 Mar 8.

Retrospective study of porcine circovirus 3 infection in China.

Sun J1,2, Wei L3, Lu Z4, Mi S2, Bao F2,5, Guo H2, Tu C2,5, Zhu Y1, Gong W2.

Author information

1
Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
2
Institute of Military Veterinary, Academy of Military Medical Sciences, Academy of Military Sciences, Changchun, China.
3
Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
4
College of Life Sciences and Engineering, Foshan University, Foshan, China.
5
Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, China.

Abstract

PCV3 is an emerging swine virus associated with porcine dermatitis and nephropathy syndrome (PDNS), reproductive failure, respiratory diseases and systematic inflammation. Although first identified in 2015, the earliest case has been traced back to 2009 in the United States. In China, PCV3 infection was first detected in 2015, but little information has been available about its occurrence and prevalence there before 2015. In this study, 200 porcine clinical samples collected from 20 provinces, five autonomous regions and four municipalities between 1990 and 1999 were analysed for PCV3 infection by PCR. Results showed that 6.5% of the porcine samples collected from eight provinces and one autonomous region were PCV3 positive, with the earliest cases occurring in 1996. Nucleotide sequence analysis showed that PCV3 strains obtained in this study shared 96.6%-99.7% and 97.1%-99.4% sequence identity at the ORF2 gene and genome levels with all available reference strains from China and other countries, indicating the high genetic stability of PCV3 over the past 20 years.

KEYWORDS:

China; PCV3; phylogenetic analysis; retrospective analysis

PMID:
29521007
DOI:
10.1111/tbed.12853
[Indexed for MEDLINE]

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