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Helicobacter. 2018 Jun;23(3):e12469. doi: 10.1111/hel.12469. Epub 2018 Mar 8.

Beneficial effect of Burdock complex on asymptomatic Helicobacter pylori-infected subjects: A randomized, double-blind placebo-controlled clinical trial.

Author information

1
Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung City, Taiwan.
2
School of Medicine, Chung Shan Medical University, Taichung City, Taiwan.
3
Department of Chinese Medicine, Taichung Hospital Ministry of Health and Well-being, Taichung, Taiwan.
4
School of Nutrition, Chung Shan Medical University, Taichung City, Taiwan.
5
Department of Neurology, Chung Shan Medical University Hospital, Taichung City, Taiwan.
6
School of Health Diet and Industry Management, Chung Shan Medical University, Taichung City, Taiwan.

Abstract

BACKGROUND:

Burdock complex (BC) constitutes of burdock (Arctium lappa), angelica (Angelica sinensis), gromwell (Lithospermum erythrorhizon), and sesame (Sesamum indicum) oil, which are commonly used in traditional Chinese medicine (TCM) for treating various disorders. This study intended to examine the anti-H. pylori activity of BC on AGS cell model as well as in asymptomatic H. pylori-infected subjects.

MATERIALS AND METHODS:

AGS cell incubated with H. pylori and treated with BC to evaluate the minimum inhibition concentration (MIC), cell viability (MTT) anti-adhesion activity, and inflammatory markers. In case of clinical trial, H. pylori-positive subjects (urea breath test [UBT] >10%, n = 36) were enrolled and requested to intake BC (n = 19) or placebo (n = 17) for 8 weeks. Antioxidant capacity, total phenol, UBT, inflammatory markers were analyzed at the initial, 4th, 8th, and 10th weeks. Moreover, the endoscopic examination was carried out on baseline and 10th week.

RESULTS:

In vitro studies showed that BC treatment significantly inhibited (P < .05) the inflammatory markers and adhesion of H. pylori to AGS cell. However, H. pylori-infected subject ingested with BC for 8 weeks significantly decreased (P < .05) the UBT value, inflammatory markers with improved antioxidant activity, and phenolic levels as compared to placebo. Also, consumption of BC considerably healed the ulcer wound.

CONCLUSION:

Overall, the BC could attenuate H. pylori infection by inhibiting H. pylori adhesion and subsequent inflammatory response on the gastric epithelial cell (AGS) as well as clinically ameliorated UBT, antioxidant capacity, and alleviated inflammation to display its anti-H. pylori activity.

KEYWORDS:

Helicobacter pylori ; AGS cells; Burdock complex; antioxidant capacity; inflammation

PMID:
29520881
DOI:
10.1111/hel.12469
[Indexed for MEDLINE]

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