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Exp Mol Med. 2018 Mar 9;50(3):e455. doi: 10.1038/emm.2017.289.

Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice.

Author information

1
Graduate School of Biomedical Science and Engineering, Hanyang Biomedical Research Institute, College of Medicine, Hanyang University, Seongdong-gu, Seoul, Republic of Korea.
2
Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seongdong-gu, Seoul, Republic of Korea.
3
Hanyang University Hospital for Rheumatic Disease, Hanyang University, Seongdong-gu, Seoul, Republic of Korea.
4
Department of Physiology, College of Medicine, Hanyang University, Seongdong-gu, Seoul, Republic of Korea.

Abstract

Transient receptor potential vanilloid 1 (TRPV1) affects mood and neuroplasticity in the brain, where its role is poorly understood. In the present study we investigated whether capsaicin (8-methyl-N-vanillyl-trans-6-nonenamide), an agonist of TRPV1, induced chromatin remodeling and thereby altered gene expression related to synaptic plasticity. We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters. Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression. Taken together, our findings implicate HDAC2 in capsaicin-induced transcriptional regulation of synaptic molecules and support the view that HDAC2 is a molecular link between TRPV1 activity and synaptic plasticity.

PMID:
29520110
PMCID:
PMC5898893
DOI:
10.1038/emm.2017.289
[Indexed for MEDLINE]
Free PMC Article

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