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Mater Sci Eng C Mater Biol Appl. 2018 Mar 1;84:90-98. doi: 10.1016/j.msec.2017.11.026. Epub 2017 Nov 23.

Therapeutic and technological potential of 7-chloro-4-phenylselanyl quinoline for the treatment of atopic dermatitis-like skin lesions in mice.

Author information

1
Laboratório de Pesquisa em Farmacologia Bioquímica - LaFarBio - Grupo de Pesquisa em Neurobiotecnologia, CCQFA - Universidade Federal de Pelotas, UFPel, P.O. Box 354, 96010-900 Pelotas, RS, Brazil.
2
Laboratório de Tecnologia e Desenvolvimento de Compósitos e Materiais Poliméricos (LaCoPol), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
3
Laboratório de Síntese Orgânica Limpa - LASOL - CCQFA, Universidade Federal de Pelotas, UFPel, P.O. Box 354, 96010-900 Pelotas, RS, Brazil.
4
Laboratório de Pesquisa em Farmacologia Bioquímica - LaFarBio - Grupo de Pesquisa em Neurobiotecnologia, CCQFA - Universidade Federal de Pelotas, UFPel, P.O. Box 354, 96010-900 Pelotas, RS, Brazil. Electronic address: cristiane_luchese@yahoo.com.br.
5
Laboratório de Pesquisa em Farmacologia Bioquímica - LaFarBio - Grupo de Pesquisa em Neurobiotecnologia, CCQFA - Universidade Federal de Pelotas, UFPel, P.O. Box 354, 96010-900 Pelotas, RS, Brazil. Electronic address: ethelwilhelm@yahoo.com.br.

Abstract

This study investigated the main effects of the oral treatment with 7-chloro-4-phenylselanyl quinoline (4-PSQ) on symptoms, inflammatory and oxidative parameters in an atopic dermatitis (AD) model in BALB/c mice. In addition, the possibility of antioxidant property of 4-PSQ improves the potential of a biofilm (based on chitosan/poly(vinyl alcohol) (PVA)/ bovine bone powder (BBP)) for the treatment of AD-like skin lesions was evaluated. 2,4-Dinitrochlorobenzene (DNCB) was applied to the dorsal skin on days 1-3 for sensitization. Mice were challenged with DNCB on the ear (on days 14-29) and dorsal skin (on days 14, 17, 20, 23, 26, and 29) and treated with 4-PSQ, dexamethasone, biofilm (biofilm sample without 4-PSQ) or 4-PSQ-loaded biofilms. On the day 30, skin severity scores and scratching behavior were determined. After that, animals were sacrificed, and ears and dorsal skin were removed for determination of inflammatory and oxidative parameters. DNCB induced the skin lesions, scratching behavior and ear swelling, increased myeloperoxidase (MPO) activity (ear and back) and reactive species (RS) levels (back). 4-PSQ, 4-PSQ-loaded biofilms and biofilm treatments ameliorated skin severity scores, scratching behavior and inflammatory response induced by DNCB. 4-PSQ and 4-PSQ-loaded biofilm treatments partially protected against the increase in the RS levels induced by DNCB. Our results revealed that the incorporation of 4-PSQ improved the therapeutic effect of the biofilm. The efficacy of 4-PSQ in treating AD-like lesions was similar or better than dexamethasone. In summary, 4-PSQ has a potential therapeutic advantage in the treatment and management of AD.

KEYWORDS:

Biofilm; Dermatitis; Inflammation; Quinoline; Selenium; Skin

PMID:
29519447
DOI:
10.1016/j.msec.2017.11.026
[Indexed for MEDLINE]

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