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Phytomedicine. 2018 Mar 1;41:1-6. doi: 10.1016/j.phymed.2018.01.013. Epub 2018 Jan 31.

Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain.

Author information

1
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 10 Prospekt Lavrentyeva, Novosibirsk 630090, Russia. Electronic address: shevelev@bionet.nsc.ru.
2
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 10 Prospekt Lavrentyeva, Novosibirsk 630090, Russia.
3
Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch, Russian Academy of Sciences, 3 Institutskaya Str., Novosibirsk 630090, Russia.
4
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 10 Prospekt Lavrentyeva, Novosibirsk 630090, Russia; Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russia.
5
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 10 Prospekt Lavrentyeva, Novosibirsk 630090, Russia; Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russia; Tomsk State University, 36 Lenina Avenue, Tomsk 634050, Russia.

Abstract

BACKGROUND:

As the standard clinically used hypotensive medicines have many undesirable side effects, there is a need for new therapeutic agents, especially ones of a natural origin.

PURPOSE:

One possible candidate is extract from the mushroom Reishi (Ganoderma lucidum), which is used in the treatment and prevention of many chronic diseases.

STUDY DESIGN AND METHODS:

To study the effectiveness of Reishi, which grows in the Altai Mountains, as an antihypertensive agent, we intragastrically administered Reishi water extract to adult male hypertensive ISIAH (inherited stress-induced arterial hypertension) rats.

RESULTS:

After seven weeks, Reishi therapy reduced blood pressure in experimental animals at a level comparable to that of losartan. Unlike losartan, intragastric Reishi introduction significantly increases cerebral blood flow and affects cerebral cortex metabolic patterns, shifting the balance of inhibitory and excitatory neurotransmitters toward excitation.

CONCLUSION:

Changes in cerebral blood flow and ratios of neurometabolites suggests Reishi has a potential nootropic effect.

KEYWORDS:

Brain metabolites; Hypertension; Reishi

PMID:
29519314
DOI:
10.1016/j.phymed.2018.01.013
[Indexed for MEDLINE]

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