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BMB Rep. 2018 Apr;51(4):200-205.

Early potential effects of resveratrol supplementation on skeletal muscle adaptation involved in exercise-induced weight loss in obese mice.

Author information

1
Sports and Health Research Center, Tongji University Department of Physical Education, Shanghai 200092, China.
2
Tongji University School of Medicine, Shanghai 200092, China.
3
Chung-Ang University College of Medicine, Seoul 06973, Korea.
4
Tongji University School of Life Sciences and Technology, Shanghai 200092, China.
5
Key Laboratory of Adolescent Health Assessment and Exercise Intervention, East China Normal University, Shanghai 200241, China.

Abstract

Exercise and resveratrol supplementation exhibit anti-obesity functions in the long term but have not been fully investigated yet in terms of their early potential effectiveness. Mice fed with high-fat diet were categorized into control (Cont), exercise (Ex), resveratrol supplementation (Res), and exercise combined with resveratrol supplementation (Ex + Res) groups. In the four-week period of weight loss, exercise combined with resveratrol supplementation exerted no additional effects on body weight loss but significantly improved whole-body glucose and lipid homeostasis. The combined treatment significantly decreased intrahepatic lipid content but did not affect intramyocellular lipid content. Moreover, the treatment significantly increased the contents of mtDNA and cytochrome c, the expression levels of peroxisome proliferator-activated receptor gamma coactivator-1 alpha and its downstream transcription factors, and the activities of ATPase and citrate synthase. However, exercise, resveratrol, and their combination did not promote myofiber specification toward slow-twitch type. The effects of exercise combined with resveratrol supplementation on weight loss could be partly due to enhanced mitochondrial biogenesis and not to fiber-type shift in skeletal muscle tissues. [BMB Reports 2018; 51(4): 200-205].

PMID:
29519293
PMCID:
PMC5933216
DOI:
10.5483/bmbrep.2018.51.4.236
[Indexed for MEDLINE]
Free PMC Article

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