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Ann Otol Rhinol Laryngol. 2018 May;127(5):297-305. doi: 10.1177/0003489418759113. Epub 2018 Mar 9.

Effect of Fentanyl Nasal Packing Treatment on Patients With Acute Postoperative Pain After Nasal Operation: A Randomized Double-Blind Controlled Trial.

Author information

1
1 Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Gangneung, Korea.
2
2 Department of Otorhinolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Gangneung, Korea.
3
3 Department of Preventive Medicine & Public Health, College of Medicine, Catholic Kwandong University, Gangneung, Korea.
4
4 Department of Rehabilitation Medicine, Chungdam Hospital, Seoul, Korea.
5
5 Department of Pharmacy, Asan Medical Center, University of Ulsan College of Medicine, Gangneung, Korea.
6
6 Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Gangneung, Korea.
7
7 Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island, USA.

Abstract

PURPOSE:

Nasal packing is an option for bleeding control after endoscopic sinus surgery and septoplasty. Although new packing materials have been developed, patients still suffer from pain and require additional analgesics treatments. In this study, a prospective, randomized, and double-blind controlled trial was designed to evaluate the effect of fentanyl-soaked packing on pain after endoscopic sinus surgery and septoplasty.

METHODS:

One hundred fifty-two patients who underwent nasal surgeries due to chronic rhinosinusitis or nasal septal deviation were enrolled in this study. At the end of operation, 50 mcg fentanyl-soaked biodegradable synthetic polyurethane foams packing Nasopore or Merocel were applied to a group of 79 patients, and saline-soaked ones were applied to another group of 73 patients. To evaluate the influence of fentanyl on postoperative nasal pain, patients' conditions were assessed via means of Numeric Rating Scale, patient satisfaction, and Ramsay Sedation Scale. In addition, symptoms of headache or sore throat and any signs of cardiopulmonary-relevant indicators were monitored.

RESULTS:

The fentanyl group had significantly decreased Numeric Rating Scale and increased patient satisfaction in every operation type for the majority of postoperative time periods ( P < .05) with reduced postoperative headache and sore throat compared to the control group. The fentanyl group showed a higher score on Ramsay Sedation Scale than the control group ( P < .05 in group including endoscopic sinus surgery). There were no significant differences in cardiopulmonary-relevant indicators between the 2 groups ( P > .05).

CONCLUSION:

Fentanyl group showed significantly reduced postoperative pain without serious adverse effects. We suggest that topical fentanyl application to nasal packs can be a useful method to reduce pain during the early postoperative period after endoscopic sinus surgery and septoplasty.

KEYWORDS:

Septoplasty; endoscopic sinus surgery; fentanyl; fentanyl-soaked packing; nasal packing; postoperative pain

PMID:
29519133
DOI:
10.1177/0003489418759113
[Indexed for MEDLINE]

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