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Ann Nutr Metab. 2018;72(3):223-230. doi: 10.1159/000487272. Epub 2018 Mar 8.

Vitamin D Levels, Body Composition, and Metabolic Factors in Asian Indians: Results from the Metabolic Syndrome and Atherosclerosis in South Asians Living in America Pilot Study.

Author information

1
Division of Endocrinology, University of California, San Francisco, California, USA.
2
Division of Reproductive Endocrinology, Keck School of Medicine, Los Angeles, California, USA.
3
Division of General Internal Medicine, University of California, San Francisco, California, USA.

Abstract

BACKGROUND/AIMS:

Asian Indians have a high prevalence of vitamin D deficiency and metabolic syndrome. Vitamin D deficiency is associated with an increased risk of cardiovascular disease and diabetes.

METHODS:

We performed a cross-sectional study of 150 Asian Indians (50% male) from the San Francisco Bay Area. We assessed the association between 25-OH vitamin D (25-OHD) levels and vitamin D deficiency with body composition (anthropometric and radiographic measures) and metabolic outcomes.

RESULTS:

In both men and women, the presence of vitamin D deficiency was associated with higher systolic (p = 0.004) and diastolic (p = 0.01) blood pressure, and fasting glucose (p = 0.01). Only in women, vitamin D deficiency status was associated with higher body mass index (BMI), waist-to-hip ratio, visceral fat area, and hepatic fat content after adjusting for age, income, and physical activity level. In women, 25-OHD was also associated with fasting glucose after adjusting for age, income, and physical activity and further adjusting for BMI and waist circumference (β -2.1, 95% CI -0.86 to -0.01, p = 0.04). This association between vitamin D deficiency and metabolic parameters was not significant in men.

CONCLUSIONS:

A lower level of 25-OHD and vitamin D deficiency were associated with higher levels of metabolic factors among Asian Indians. Our findings suggest that 25-OHD metabolism may differ by the distribution of adipose tissue and involve previously unexplored pathways accounting for the variability in the role of vitamin D in cardiovascular disease.

KEYWORDS:

25-OH Vitamin D; Asian Indians; Body composition; Cardiovascular disease; Diabetes; Metabolism

PMID:
29518767
PMCID:
PMC5907927
DOI:
10.1159/000487272
[Indexed for MEDLINE]
Free PMC Article

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